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Erectile Dysfunction Drugs might help Treat Oesophageal Cancer, Study Finds

Erectile dysfunction drugs could help deal with oesophageal cancer, study discovers

22 June 2022

An ingredient in impotence medication might help deal with oesophageal cancer, a research study has actually discovered.

Southampton researchers found the PDE5 inhibitors in the medication assisted penetrate the barrier of cells around tumours, enabling chemotherapy drugs to reach cancer cells.

One in 10 patients presently endures the disease, which is found anywhere in the gullet, for 10 years or more.

The research study was funded by Cancer Research UK. The next stage is a medical trial.

Prof Tim Underwood, lead author of the study, said the discovery could improve these survival rates.

He stated a cell called the cancer-associated fibroblast, responsible for injury recovery, could be targeted with the inhibitors.

“It’s been used throughout the world in countless dosages,” he explained. “It’s safe, and we used it to cancer.”

He added it was to the scientists “wonder and surprise and pleasure” that the drug had an effect.

“We require to put this into a scientific trial where we attempt the drug type alongside chemotherapy to see if it makes the chemotherapy more reliable,” he said.

“The initial work suggests it should do, and if it does and if it’s safe, and it enhances results of chemotherapy, then it could be actually substantial for the clients I care for.”

The research study was performed using tumours from 8 cancer patients, with more tests done on mice.

Chemotherapy just helps 20% of clients in a considerable way, he stated.

“If this drug combination even enhances it by a small amount, we’re actually going to assist a a great deal of people every year to respond much better and live longer.”

Researchers at Southampton University Hospitals say that the normal outcomes of erectile dysfunction disorder drugs require additional stimulation, so would not impact cancer clients in the very same way.

Prof Underwood said the primary negative effects would be “a bit of headache, a little bit of flushing”.

Terry Daly, from Aldershot, Hampshire, is among the 9,500 individuals detected with oesophageal cancer in the UK every year.

It typically goes unnoticed in the early stages, with Mr Daly finding it was difficult to swallow his food and he wound up regurgitating it.

He is shortly to go through another round of chemotherapy, and said if he had the option to take the new treatment he would have “taken it with both hands”.

“The research study that is being done is absolutely fantastic,” he said.

“It is simply amazing that there are individuals out there going to spend their lives just searching for a cure, so that individuals can get on with their everyday lives and not need to go through all this stuff.

“You can’t thank these people enough for what they’re doing.”

The five-year research study has been moneyed by Cancer Research UK and the Medical Research Council.

A medical trial is expected within the next 18 months and if successful, it is hoped new treatments based upon this research study might be used within 10 years.

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Related internet links

Cancer Research UK

University Hospital Southampton

Institute of Developmental Sciences – University of Southampton

What is oesophageal cancer? – NHS

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