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Erectile Dysfunction Drugs could help Treat Oesophageal Cancer, Study Finds

Erectile dysfunction drugs might assist treat oesophageal cancer, study finds

22 June 2022

A component in impotence medication might help deal with oesophageal cancer, a study has found.

Southampton scientists found the PDE5 inhibitors in the medication helped permeate the barrier of cells around tumours, enabling chemotherapy drugs to reach cancer cells.

One in 10 patients currently survives the disease, which is found throughout the craw, for 10 years or more.

The study was moneyed by Cancer Research UK. The next stage is a clinical trial.

Prof Tim Underwood, lead author of the study, stated the discovery could improve these survival rates.

He said a cell understood as the cancer-associated fibroblast, responsible for injury healing, could be targeted with the inhibitors.

“It’s been used throughout the world in countless dosages,” he explained. “It’s safe, and we applied it to cancer.”

He included it was to the scientists “wonder and surprise and pleasure” that the drug had an impact.

“We need to put this into a medical trial where we attempt the drug type together with chemotherapy to see if it makes the chemotherapy more reliable,” he said.

“The preliminary work suggests it should do, and if it does and if it’s safe, and it enhances results of chemotherapy, then it could be actually considerable for the patients I take care of.”

The research study was performed utilizing tumours from 8 cancer clients, with further tests done on mice.

Chemotherapy just assists 20% of oesophageal cancer clients in a considerable method, he stated.

“If this drug mix even improves it by a percentage, we’re truly going to assist a big number of individuals every year to react better and live longer.”

Researchers at Southampton University Hospitals state that the typical outcomes of erectile dysfunction disorder drugs require additional stimulation, so would not affect cancer clients in the same way.

Prof Underwood stated the main negative would be “a little bit of headache, a bit of flushing”.

Terry Daly, from Aldershot, Hampshire, is among the 9,500 people identified with oesophageal cancer in the UK every year.

It typically goes unnoticed in the early stages, with Mr Daly discovering it was tough to swallow his food and he ended up regurgitating it.

He is soon to undergo another round of chemotherapy, and said if he had the alternative to take the new treatment he would have “taken it with both hands”.

“The research study that is being done is absolutely great,” he stated.

“It is just extraordinary that there are people out there happy to invest their lives simply trying to discover a treatment, so that people can get on with their daily lives and not have to go through all this things.

“You can’t thank these individuals enough for what they’re doing.”

The five-year study has been funded by Cancer Research UK and the Medical Research Council.

A scientific trial is anticipated within the next 18 months and if effective, it is hoped brand-new treatments based upon this research study might be used within 10 years.

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Related web links

Cancer Research UK

University Hospital Southampton

Institute of Developmental Sciences – University of Southampton

What is oesophageal cancer? – NHS

The BBC is not accountable for the material of external websites.

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